Prescribed to Millions
"ULTRAM® (tramadol hydrochloride tablets) is a prescription medication indicated for the management of moderate to moderately severe pain. ULTRAM received U.S. Food and Drug Administration (FDA) approval in March 1995. Tramadol has been prescribed in more than 55 million patients worldwide and ULTRAM has been prescribed in more than 21 million patients in the United States."

Synthetic Analgesic
ULTRAM is a centrally acting synthetic analgesic, not a non-steroidal anti-inflammatory drug (NSAID). ULTRAM has no anti-inflammatory activity and no potential for prostaglandin-mediated side effects. Unlike NSAIDs, ULTRAM does not have the potential to compromise the efficacy of certain antihypertensive agents (diuretics, beta blockers, and ACE-inhibitors).

For patients with moderate to moderately severe chronic pain not requiring rapid onset of analgesic effect, the tolerability of ULTRAM can be improved by initiating therapy with the following titration regimen: ULTRAM should be started at 25 mg/day qAM and titrated in 25 mg increments as separate doses every 3 days to reach 100 mg/day (25 mg q.i.d.). Thereafter the total daily dose may be increased by 50 mg as tolerated every 3 days to reach 200 mg/day (50 mg q.i.d.). After titration, ULTRAM 50 to 100 mg can be administered as needed for pain relief every 4 to 6 hours not to exceed 400 mg/day.

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